The End Of Drug Discovery

We are in desperate need of new medicines for the major diseases facing us in the 21st century such as Alzheimer's and obesity. And we are running out of antibiotics that are effective against bacteria that are now resistant to many old varieties. As bringing new and improved drugs to patients becomes more difficult and more expensive - it can take twenty years and around $1 billion to bring a medicine to market - Geoff Watts asks what's gone wrong and what can be done to get new pharmaceutical treatments to patients.

Geoff talks to a number of researchers who have worked both within the pharmaceutical industry and publicly funded laboratories to get their views on why the source of drugs has dried up. These include Dr Patrick Vallance, of global pharmaceutical giant GSK, Professor Paul Workman of the Institute of Cancer Research, Professor Chas Bountra of Oxford University's Structural Genomics Consortium, and Dr Mike Dawson of biotech company Novacta Biosystems.

They argue that the age of the blockbuster drug which can treat millions of patients is over and that we don't know enough science to be able to find treatments for conditions like Alzheimer's disease. The industry is risk averse and regulations to ensure that drugs are safe and effective are burdensome. Tilli Tansey, Professor of the History of Modern Medical Science at Queen Mary University in London puts the state of drug discovery in its historical context.

Geoff finds out that these experts believe that there needs to be a fundamental change in the drug development process, and the key ingredient is collaboration - between industry and academia and between different drug companies. He also discovers that the medical charity, the Wellcome Trust, is putting money into the development of antibiotics, a field not of interest to many pharmaceutical companies.

Editor: Deborah Cohen.

Geoff Watts asks why the source of new medical drugs is drying up.